Embarking on Lipid Exploration: A Journey into Cellular Dynamics

In the realm of lipid research, scientists Sarah Cohen and Philipp Scherer share their intriguing paths and profound interest in lipids. Cohen delves into her journey, ignited during her postdoctoral work, transitioning from the cell biology of viruses to the captivating world of organelle biogenesis and turnover. Meanwhile, Scherer’s fascination with lipids originated at the cellular level, evolving through mitochondrial protein import studies and eventually leading to a focus on the physiology of fat cells. Both researchers found themselves drawn into the intricate world of lipids, unraveling its mysteries through their distinctive scientific pursuits.

Lipid Droplets Take Center Stage: A Focus on Cohen’s Lab

Cohen’s postdoctoral endeavors, particularly under Jennifer Lippincott–Schwartz’s guidance, steered her towards the study of lipid droplets. Over the past decade, her lab has honed in on these cellular compartments, unraveling their dynamics and the fascinating exchange of materials, including lipids, at membrane contact sites. The unique structure of lipid droplets, where a hydrophobic core is encased by a phospholipid monolayer, sets them apart, making their study a captivating exploration outside traditional vesicular trafficking pathways.

Beyond Boundaries: Lipid Metabolism in Neurodegenerative Diseases

Expanding the horizons of lipid research, Cohen’s lab has recently delved into the role of lipid metabolism and trafficking in neurodegenerative diseases. This dynamic shift broadens the scope of lipid exploration, connecting it to critical health contexts and paving the way for innovative insights into the intricate interplay between lipids and neurological disorders.

Scherer’s Journey: From Cellular Trafficking to Whole-Body Physiology

Scherer’s interest in lipids unfolded as he navigated the intricacies of cellular trafficking during his postdoctoral tenure at Harvey Lodish’s lab. Transitioning to his own lab at Albert Einstein, Scherer embraced the physiology of fat cells, naturally delving into the world of lipids. His journey, rooted in mitochondrial protein import studies, gradually expanded to encompass the whole-body level, focusing on classical secretory proteins and signaling lipids that play pivotal roles in metabolism.

The Essence of the Deuel Meeting: A Unique Lipid Symposium

Both researchers share their perspectives on the renowned Deuel meeting, a gathering that stands out as the most significant lipid conference. Cohen’s experience in Monterrey, California, left her impressed by the diverse talks covering lipids in various physiological and disease contexts. Scherer, who has been part of the Deuel meeting’s board for years, emphasizes its unique setting, fostering a small and informal environment conducive to discussions, interactions, and a level playing field for all attendees.

2025 Deuel Meeting: Bridging Cellular and System Levels

Looking ahead to the 2025 Deuel meeting, Cohen and Scherer outline their vision. They prioritize diversity among speakers, aiming for a varied mix in topics, geography, gender, race, and ethnicity. Organizing the meeting by organ systems dedicated to lipid metabolism, including liver and fat tissue, kidney, heart, brain, and the GI tract, reflects their commitment to comprehensive coverage. The meeting’s structure provides a platform to explore cellular aspects such as lipid droplets, fatty acid metabolism, and organelle contact sites while inviting industry speakers to bridge the gap between academia and pharmacological applications.

Hot Topics in Lipid Research: A Glimpse into the Future

The duo anticipates covering cutting-edge topics in lipid research during the 2025 meeting. Lipotoxicity, lipid peroxidation, and ferroptosis, a cell-death pathway dependent on lipid peroxidation, stand out as crucial areas of exploration. Sterols, lipid rafts, and novel therapeutics targeting lipid metabolism join the lineup. The researchers aim to contextualize these discussions within the ongoing revolution in weight loss drugs, providing insights into the implications for lipid homeostasis from a basic science perspective.

Collaborative Harmony: Working Together for a Remarkable Program

Cohen and Scherer share their collaborative experience in organizing the Deuel meeting, highlighting the synergy between their expertise. Cohen expresses excitement about co-organizing with Scherer, acknowledging his wealth of knowledge as a mentor. Scherer, in turn, commends their complementary skills, emphasizing the potential for a captivating program in the picturesque Long Beach, California. Their collaboration symbolizes a blend of experience and fresh perspectives, promising a memorable meeting for lipid enthusiasts.

A Grand Finale: Anticipating Fond Memories and Engaging Discussions

As the 2025 Deuel meeting unfolds, Cohen and Scherer aspire to create an atmosphere filled with engaging discussions and exciting scientific revelations. Their shared goal is to offer attendees a unique and enriching experience, transcending the traditional conference format. With a focus on both cellular intricacies and systemic implications, the meeting aims to leave a lasting impact on lipid research, fostering fond memories for all participants over the course of a stimulating and entertaining gathering.